Baloo is a two year old, phantom tri-color (black, tan, white) toy poodle AKC registered. He has dark nose and eyes. He weights 9 lbs.
Links
AKC Three Generation Pedigree
DNA Test Results from Embark
DNA Test Results Impotant to Know
1. Intervertebral Disc Disease (Type I)
Baloo inherited one copy of the variant tested. Since Baloo inherited one copy of the variant tested, he will pass this variante to approximately 50% of his off springs.
The CDDY/IVDD mutation is NOT a deterministic mutation, but increases risk, in a dominant fashion. The CDDY/IVDD mutation is found at extremely high frequency in toy and miniature poodles, which undoubtedly explains why they are higher risk. UC Davis estimates that only 16% of dogs would be clear of the mutation, and more than a third of the dogs they tested in their study had two copies. This means that breeders cannot eliminate all dogs with the mutation from their breeding pool! That would eliminate most dogs. This would be bad because it will decrease the genetic variety in the breeding pool. UCDavis says they have never found this mutation in a standard poodle. For more information, see pages 21-23 of the educational material contained in the Sales Contract.
2. ALT Activity
Baloo inherited one copy of the variant tested. this is not a condition or a genetic issuee. He has one copy of a variant associated with reduced ALT activity as measured on veterinary blood chemistry panels. ALT is often used as an indicator of liver health and Baloo is likely to have a lower than average resting (good) ALT activity. As such, an increase in Baloo’s ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges. Thefore, it is important to inform Baloo's veterinary about this result when blood test are performed to ensure that if an increase in ATL that is within refernece ranges does not go unnoticed. Baloo could pass this variant to approximately 50% of his offsprings (puppies). Lower-than-average baseline ALT activity is typically not a reason to remove a dog from a breeding program. See page 24 of the educational material contained in the Sales Contract.
3. Progressive Retinal Atrophy, prcd
Baloo inherited one copy of the variant tested. This variant should not impact Baloo’s health. This variant is inherited in an autosomal recessive manner, meaning that a dog needs two copies of the variant to show signs of this condition. Baloo is unlikely to develop this condition due to this variant because he only has one copy of the variant.
PRA-prcd is a retinal disease that causes progressive, non-painful vision loss. The retina contains cells, called photoreceptors, that collect information about light and send signals to the brain. There are two types of photoreceptors: rods, for night vision and movement, and cones, for day vision and color. This type of PRA leads to early loss of rod cells, leading to night blindness before day blindness. See page 26 of the educational material contained in the Sales Contract.
